Dr. DeMichele is a Professor of Medicine and Epidemiology at the University of Pennsylvania and holds the Jill and Alan Miller Endowed Professorship in Breast Cancer Excellence. Dr. DeMichele has been the Co-Leader of the Breast Cancer Research Program in the Abramson Cancer Center since 2005, where she also directs both the Breast Cancer Clinical Trials Program and the Breast Cancer TRACR Biobank. Her research program is focused on drug development, innovative clinical trial design and investigation of biomarkers for precision therapy. As Co-Director of Penn’s 2-PREVENT Breast Cancer Translational Center of Excellence, she leads a multidisciplinary team to tackle the problem of breast cancer recurrence through novel clinical trials targeting disseminated and circulating tumor cells. She also serves as Co-Chair of the Breast Committee of the ECOG/ACRIN Cooperative Group, Trial Operations Chair of the I-SPY2 multicenter, neoadjuvant trial, and Penn PI for the Translational Breast Cancer Research Consortium. She has developed numerous targeted therapies, including phase I and II development of the CDK4/6 inhibitor, Palbociclib and is currently co-PI of the international PALLAS adjuvant trial and PATINA trial for Her2+ disease. She has authored over 150 publications in high impact journals such as the New England Journal of Medicine and Journal of the American Medical Association (JAMA), and her research is has been funded by the NIH, NCI, DOD, Komen Foundation, Breast Cancer Research Foundation, American Society of Clinical Oncology, American Cancer Society and other philanthropic sources. She is an Associate Editor at Breast Cancer Research. She has chaired the Metastatic Breast Cancer Scientific Program and Breast Cancer and Clinical Trials Education Committees of the American Society of Clinical Oncology, and serves on the ASCO Guidelines Advisory Committee, NCCN Clinical Research Committee in addition to service on other ASCO committees, and on the American Board of Internal Medicine Oncology Subspecialty Board. She has a dual appointment as a Senior Scholar in the Center for Clinical Epidemiology and Biostatistics, where she developed a graduate course on clinical trials and translational research and serves as thesis advisor to Masters and PhD candidates.